They will affect the handling characteristics. The wrong combination may also adversely VSS, causing limp mode. As to good or bad in the handling department, that is pretty much in the eye of the beholder. As a new rider, I suggest you ride a while, and wear out a set of OEM tires first, before deciding you need something different. The Spyder VSS is designed and calibrated around the OEM tires. That is not saying that others won't work, but you still lack the experience to respond to any changes they bring, and the VSS may not save your butt as readily. JMHO