Is that pain occurring
WHILE you're riding, or
AFTER you ride??
Just to start with, Spyders require a
LOT more physical involvement to ride spiritedly, waaaay more than just about any 2 wheeled bike, simply because they don't have the 2 dirty great big gyroscopes (wheels) to help things stay upright, lean thru a corner, etc - and all of those forces need to be counteracted by the Spyder
Ryder, so unless you're just sitting astride and tootling around the place, you're very likely gonna be working muscles that you forgot you had decades ago!!!
Beyond that, a Spyder really
IS a completely different animal to any 2 wheeled bike, and you
WILL be using different muscles and skills to ride it, even if you aren't yet showing a clean pair of heels to all the wannabe racers thru the twisty stuff, so some differences and tired muscles etc are to be expected; but if you're getting shooting pains or nerve glitches etc, there could be something that needs to be addressed pdq! Generally, most 'new Spyder Ryder' pains & aches come from being too tense, hanging on too tight, and fighting the Spyder instead of gently guiding it and letting it wander a bit!! Those sorts of pains generally ease over time as the new Ryder learns to relax, and in many instances, effectively UNLEARNS many of the muscle memory responses and skills that years of 2 wheel riding have developed.
Besides, on a Spyder, you have something more than 3 times the contact patch that a 2 wheeled bike has,
AND it's spread out in a wide line
ACROSS your direction of travel instead of a very small and narrow contact patch that's in line with your direction of travel, so instead of being able to avoid most of it and only react to a tiny bit of it anyway, every little bump or twitch will result in some reaction/response in the bike - and you need to learn to let that happen, don't fight the reaction, don't tense up at the bumps & twitches or try to dodge things by forcing the bike to avoid, just accept that it's a different ride, look waaaaayyy out ahead, and gently ride and guide your Spyder along your chosen path without trying to force it to be exactly on track to the millimetre.
Over to you.