Mullholland Drive is one of the most dangerous roads in America. I have ridden it many times, but never enjoyed it. It is close to the ocean, twisty, and has the Rock Store on it. Otherwise, it would just be another SoCal road.
Much better roads north of LA, IMHO. These roads have much less traffic, are as twisty or even more so, and go from sea level up to several thousand feet and back down.
Ride up to Gorman on I-5, take the Frazier Park exit to Lake of the Woods. Then take Lockwood Valley Road. You will not believe you are only ~50 miles, as a crow flies, from LA! Extremely remote area. Go left to Ojai on
Cal 33.
When you get to Ojai, you will be exhausted, but the grin on your face can't be removed for at least a week! Oh, stop at the Deer Lodge in Ojai for some barley and venison soup. Good stuff!!
Many more roads in the area that are fantastic to ride. San Francisquito Road, Lake Hughes Road, Bouquet Canyon (part of it), Angles Crest Highway, Kennedy Woods road off Cal 396 near Ridgecrest. Many more. And, this doesn't include all of the dirt bike places to ride. Literally, a dessert full.
Joe T.