Like most everyone has said it is up to you and how you feel. But you also have to take into account the type of roads that you will be traveling on. Interstates a 4 to 5 hour is really nothing but if you are doing two lanes back roads that time could only be 200 miles. Since this is your first long trip I suggest a little planning ahead of time and you will be okay. The last trip I made ( two weeks 3500 miles, the wife and a trailer) I averaged 200 to 300 miles away but I was on two lanes with a lot of curves so average speed was around 40 MPH. Good luck and enjoy.