I don't have any facts but I would bet that the bike would be to lean for comfort if we remove both without a tuning device. As of right now I can not find anyone offering a tuner for the 2013 yet. For the best performance I think we need to remove the cat, add free flowing muffler, and remove factory airbox and install the Kewl Metal high flow intake system. With the 50lbs of weight reduction and the more air in and more air out we should be able to get some good gains! After that there isn't anything else let on the aftermarket to improve performance. You would think that after 6 years we would have cam options, big bore kits, and several high flow intake options with cool air intake ducting to foglight holes.
I agree I have a ST and want more power, removing cat, good after market free flowing mufflar and Kewl high flow intake will make a great difference in power. Like you I have not been able to find tuner, that is until now. Dynojet Power Commander V has just come out with one for the 2013 ST, RSS, and RT. Check Revzilla web site, selling for $411.63, their phone number is 877-792 9455. You can also check it out on Dynojet web site. How it compares to what and when Power Commander or Two Bros. Juice Box, I do not know since they have none yet for the 2013's.