I didn't come from a Harley, but a 1700 Kawi Voyager, so we're talking about the same size and weight. As LB said above, the falling over fear was what drove me to the Spyder. At 70, I'm not quite as nimble nor strong as I once was, that, two replaced knees, and a hip, so I figured that if I dropped it, it would be a battle getting it up.
I will say, the first trip I was saying to myself, "What have I done" but after I got used to it, I love it. I don't dislike the semi-auto but I think I'd prefer the standard.
A friend of mine said that it was boring riding it. Don't know how he figures that, as you get to lean in the corners... just the opposite way.
Power - it puts my old Kawi to shame.
Throttle control being fly by wire... mehhh, a bit different feel, for lack of a better word, not bad, just different.
It's a different beast for sure, but I have no regrets about buying it.