Originally Posted by
DubuqueSpyderRyder
I would recommend you make your way east to the Mississippi river and follow the roads to down LaCrosse which parallel the river. That is some of the best scenery in the area. Go through the town of LaCrosse, won't take long, it is an incredibly historic river town. From there I would follow the river road down to Prarrie du Chien. The road is literally within view of the river all the way. From Prarrie du Chien I would suggest your next stop be Cassville, Wi which is also on the river. It is the only town within 200 miles either way with a ferry across the Mississippi. Take the ferry both ways as it's a great ride, and where you'd end up in Iowa is not really on your way. From Cassville then go to Dubuque. Big town, good for an overnight, easy to hook up to several different roads directly down to St. Louis.
Safe travels,
DubuqueSpyderRyder